Date of Award

Summer 1957

Degree Type

Thesis - Restricted

Degree Name

Master of Science (MS)




Despite a large amount of work in recent years on the thyroid gland, the peripheral effects of the thyroid hormone are still poorly defined. Questions of current interest are its mode of entrance into tissues, its site and mechanism of action, and the active form of the hormone. The isolation of 1-triiodothyronine with its reported increased potency and shorter latent period when compared with thyroxine has given new insights into these problems. Therefore it was considered feasible to analyze these two hormones on the basis of their effects as the oxygen consumption of rat tissues at various times after single injections of either of the two compounds. It is felt that such a study has not only intrinsic value in further defining the nature of the thyroid hormone, but is also of worth in laying a foundation for future investigations into the tissue effects of the thyroid's secretion.



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