Date of Award

Spring 2018

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)



First Advisor

Bhagavatula, Pradeep

Second Advisor

Stover, Sheila

Third Advisor

Wirtz, Thomas


With patient medical histories continuing to increase in complexity, dental professionals are faced with the task of delivering necessary care while respecting said medical history. Though advances have been made in combating osteopathies like osteoporosis and bone-related malignancies through medicinal intervention, these same medications can alter the bone’s ability to heal properly. The result of this inability to heal can be medication-related osteonecrosis of the jaw (MRONJ). The purpose of this study was to evaluate whether patients at risk for MRONJ treated at Marquette University School of Dentistry (MUSoD) demonstrated any complications following endodontic therapies associated with MRONJ. During the course of this study, a review of electronic patient dental records (axiUm Exan Group, Coquitlam, BC) at MUSoD was performed to obtain a list of patients who are at higher risk of MRONJ based on their medical and dental histories. After a patient list was organized, a retrospective analysis of medical history, dental treatment history, MRONJ-related events, and subsequent treatment was performed using a combination of electronic and paper charts. Statistical analysis was completed for the data collected. From this study, the following conclusions were made: 1. The occurrence of untoward events following endodontic treatment was not affected by the length of time patients were on medications that increase the risk of MRONJ, or by their method of delivery (Intravenous or Oral). 2. The occurrence of untoward events following endodontic treatment was not affected by the type of endodontic procedure. 3. Endodontic procedures may be a safe and predictable option for patients at increased risk for MRONJ.


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