Date of Award

Spring 2021

Document Type


Degree Name

Master of Science (MS)


Biomedical Engineering

First Advisor

Yu, Bing

Second Advisor

Liu, Dawei

Third Advisor

Olson, Lars


Diffuse reflectance spectroscopy (DRS) is a technique for characterizing the optical properties of biological tissues and has been extensively studied for diagnosis and therapeutic monitoring of various diseases. This thesis investigates the potential use of DRS for the evaluation of mid-palatal suture maturation after expansion. The most common evaluation technique for palatal expansion is Computed Tomography (CT). The major issue with CT is that during serial radiological scanning, patients are repeatedly exposed to ionizing radiation. DRS is a non-invasive, non-ionizing method which can be used to quantify the tissue optical properties in the visible wavelength in vivo. This study demonstrates that a fiber-optic-based DRS system could be used to quantify the total hemoglobin content and scattering coefficient in the simulated dental tissue, showing its potential to be used to represent the maturation of mid-palatal suture.

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Engineering Commons