Document Type

Conference Proceeding

Language

eng

Format of Original

9 p.

Publication Date

2-15-2003

Publisher

Society of Photo-Optical Instrumentation Engineers

Source Publication

Proceedings of SPIE 5031: Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, San Diego, CA, (February 15, 2003)

Original Item ID

doi: 10.1117/12.485800

Abstract

To study the relationship between transpulomnary pressure (Ptp), intravascular pressure (Pv), and the pulmonary arterial tree structure, morphometric measurements of pulmonary arterial trees were made in intact lungs from Sprague-Dawley rats. Using cone beam micro-CT and techniques we developed for imaging small animal lungs, volumetric CT data were acquired for Ptp from 0 - 12 mmHg and Pv from 5 - 30 mmHg. The diameter, D (measured range approximately 0.08-2.0 mm), vs. pressure, P, relation can be described by D(P) = D(0)(1+ α P), where α is a distensibility coefficient. Unlike studies performed in larger animals, where changes in either Ptp or Pv had nearly identical effect on vessel distensibility, we found that there is only a small dependence of arterial diameter on Ptp in the rat. For example, using the above relation where P=Ptp and Pv is held constant at 12mmHg, alpha = 0.55±0.42(SE) %/mmHg, compared with when P=Pv and Ptp is held at 12mmHg, alpha = 2.59±0.17(SE) %/mmHg.

Comments

Published version. Published as part of the proceedings of the conference, SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, 2003: 195-203. DOI. © Society of Photo-optical Instrumentation Engineers (SPIE) 2003. Used with permission.

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