Cardiovascular Magnetic Resonance Imaging-Based Computational Fluid Dynamics/Fluid-Structure Interaction Pilot Study to Detect Early Vascular Changes in Pediatric Patients with Type 1 Diabetes

Authors

Margaret M. Samyn, Marquette UniversityFollow
Ronak Jashwant Dholakia, Stony Brook UniversityFollow
Hongfeng Wang, Marquette UniversityFollow
Jennifer Co-Vu, University of Florida College of Medicine
Ke Yan, Medical College of WisconsinFollow
Michael E. Widlansky, Medical College of Wisconsin
John F. LaDisa Jr., Marquette UniversityFollow
Pippa Simpson, Medical College of WisconsinFollow
Ramin Alemzadeh, University of Illinois at ChicagoFollow

Document Type

Article

Language

eng

Format of Original

11 p.

Publication Date

4-2015

Publisher

Springer

Source Publication

Pediatric Cardiology

Source ISSN

0172-0643

Original Item ID

doi: 10.1007/s00246-014-1071-7

Abstract

We hypothesized that pediatric patients with type 1 diabetes have cardiac magnetic resonance (CMR) detectable differences in thoracic aortic wall properties and hemodynamics leading to significant local differences in indices of wall shear stress, when compared with age-matched control subjects without diabetes. Pediatric patients with type 1 diabetes were recruited from Children’s Hospital of Wisconsin and compared with controls. All underwent morning CMR scanning, 4-limb blood pressure, brachial artery reactivity testing, and venipuncture. Patient-specific computational fluid dynamics modeling with fluid–structure interaction, based on CMR data, determined regional time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI). Twenty type 1 diabetic subjects, median age 15.8 years (11.6–18.4) and 8 controls 15.4 years (10.3–18.2) were similar except for higher glucose, hemoglobin A1c, and triglycerides for type 1 diabetic subjects. Lower flow-mediated dilation was seen for those with type 1 diabetes (6.5) versus controls (7.8), p = 0.036. For type 1 diabetic subjects, the aorta had more regions with high TAWSS when compared to controls. OSI maps appeared similar. Flow-mediated dilation positively correlated with age at diabetes diagnosis (r = 0.468, p = 0.038) and hemoglobin A1c (r = 0.472, p = 0.036), but did not correlate with aortic distensibility, TAWSS, or OSI. TAWSS did not correlate with any clinical parameter for either group. CMR shows regional differences in aortic wall properties for young diabetic patients. Some local differences in wall shear stress indices were also observed, but a longitudinal study is now warranted.

Comments

Accepted version. Pediatric Cardiology, Vol. 36, No. 4 (April 2015): 851-861. DOI. © 2015 Springer. Used with permission.

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Recommended Citation

Samyn, Margaret M.; Dholakia, Ronak Jashwant; Wang, Hongfeng; Co-Vu, Jennifer; Yan, Ke; Widlansky, Michael E.; LaDisa, John F. Jr.; Simpson, Pippa; and Alemzadeh, Ramin, "Cardiovascular Magnetic Resonance Imaging-Based Computational Fluid Dynamics/Fluid-Structure Interaction Pilot Study to Detect Early Vascular Changes in Pediatric Patients with Type 1 Diabetes" (2015). Biomedical Engineering Faculty Research and Publications. 360.
https://epublications.marquette.edu/bioengin_fac/360