Fellow Eye Changes in Patients with Nonischemic Central Retinal Vein Occlusion: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries

Authors

Alexander Pinhas, Icahn School of Medicine at Mount Sinai
Michael Dubow, New York Icahn School of Medicine at Mount Sinai
Nishit Shah, New York Eye and Ear Infirmary
Eric Cheang, New York Eye and Ear Infirmary
Chun L. Liu, New York Eye and Ear Infirmary of Mount Sinai
Moataz Razeen, New York Eye and Ear Infirmary
Alexander Gan, New York Eye and Ear Infirmary of Mount Sinai
Rishard Weitz, New York Eye and Ear Infirmary
Yusufu N. Sulai, University of Rochester
Toco Y.P. Chui, New York Eye and Ear Infirmary
Alfredo Dubra, Marquette University
Richard B. Rosen, New York Eye and Ear Infirmary

Document Type

Article

Language

eng

Publication Date

10-2015

Publisher

Lippincott Williams & Wilkins, Inc.

Source Publication

Retina

Source ISSN

1539-2864

Original Item ID

DOI: 10.1097/IAE.0000000000000586

Abstract

Purpose: Eyes fellow to nonischemic central retinal vein occlusion (CRVO) were examined for abnormalities, which might explain their increased risk for future occlusion, using adaptive optics scanning light ophthalmoscope fluorescein angiography.

Methods: Adaptive optics scanning light ophthalmoscope fluorescein angiography foveal microvascular densities were calculated. Nonperfused capillaries adjacent to the foveal avascular zone were identified. Spectral domain optical coherence tomography, ultrawide field fluorescein angiographies, and microperimetry were also performed.

Results: Ten fellow eyes of nine nonischemic CRVO and 1 nonischemic hemi-CRVO subjects and four affected eyes of three nonischemic CRVO and one nonischemic hemi-CRVO subjects were imaged. Ninety percent of fellow eyes and 100% of affected eyes demonstrated at least 1 nonperfused capillary compared with 31% of healthy eyes. Fellow eye microvascular density (35 ± 3.6 mm⁻¹) was significantly higher than that of affected eyes (25 ± 5.2 mm⁻¹) and significantly lower than that of healthy eyes (42 ± 4.2 mm⁻¹). Compared with healthy controls, spectral domain optical coherence tomography thicknesses showed no significant difference, whereas microperimetry and 2/9 ultrawide field fluorescein angiography revealed abnormalities in fellow eyes.

Conclusion: Fellow eye changes detectable on adaptive optics scanning light ophthalmoscope fluorescein angiography reflect subclinical pathology difficult to detect using conventional imaging technologies. These changes may help elucidate the pathogenesis of nonischemic CRVO and help identify eyes at increased risk of future occlusion.

Comments

Accepted version. Retina, vol. 35, No. 10 (October 2015): 2028-2036. DOI. © 2015 Lippincott Williams & Wilkins, Inc. Used with permission.

This is a non-final version of an article published in final form in Retina, vol. 35, No. 10 (October 2015): 2028-2036. DOI.

Recommended Citation

Pinhas, Alexander; Dubow, Michael; Shah, Nishit; Cheang, Eric; Liu, Chun L.; Razeen, Moataz; Gan, Alexander; Weitz, Rishard; Sulai, Yusufu N.; Chui, Toco Y.P.; Dubra, Alfredo; and Rosen, Richard B., "Fellow Eye Changes in Patients with Nonischemic Central Retinal Vein Occlusion: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries" (2015). Biomedical Engineering Faculty Research and Publications. 418.
https://epublications.marquette.edu/bioengin_fac/418