Evaluation of 70/30 D,L-PLa for Use as a Resorbable Interbody Fusion Cage

Authors

Jeffrey M. Toth, Marquette UniversityFollow
Mei Wang, Marquette University
Jeffrey L. Scifert, Medical College of Wisconsin
G. Bryan Cornwall, Shiley-Marcos School of Engineering
Bradley T. Estes, Duke University
Howard Seim, Colorado State University - Fort Collins
Simon Turner, Colorado State University - Fort Collins

Document Type

Article

Language

eng

Publication Date

10-2002

Publisher

Slack Incorporated

Source Publication

Orthopedics

Source ISSN

0147-7447

Original Item ID

DOI: 10.3928/0147-7447-20021002-03

Abstract

Titanium lumbar interbody spinal fusion devices are reported to be 90% effective for single-level lumbar interbody fusion, although radiographic determination of fusion has been debated. Using blinded radiographic, biomechanic, histologic, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) (70/30 D,L-PLa) interbody fusion device packed with autograft or rhBMP-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologic fusion was demonstrated from 3 months to 24 months. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.

Comments

Accepted version. Orthopedics, Vol. 25, No. 10 (October 2002): S1131-S1140. DOI. © 2002 Slack Incorporated. Used with permission.

Recommended Citation

Toth, Jeffrey M.; Wang, Mei; Scifert, Jeffrey L.; Cornwall, G. Bryan; Estes, Bradley T.; Seim, Howard; and Turner, Simon, "Evaluation of 70/30 D,L-PLa for Use as a Resorbable Interbody Fusion Cage" (2002). Biomedical Engineering Faculty Research and Publications. 512.
https://epublications.marquette.edu/bioengin_fac/512