Document Type

Article

Language

eng

Format of Original

8 p.; 28 cm

Publication Date

4-2016

Publisher

Elsevier

Source Publication

Neurobiology of Learning and Memory

Source ISSN

1074-7427

Original Item ID

doi: 10.1016/j.nlm.2016.02.013; PubMed Central, PMCID: PMC4820070; Shelves: QH 301 .B29x 2016 v. 130, Memorial Periodicals

Abstract

Cocaine experience affects motivation structures such as the nucleus accumbens (NAc) and its major output target, the ventral pallidum (VP). Previous studies demonstrated that both NAc activity and hedonic responses change reliably as a taste cue comes to predict cocaine availability. Here we extended this investigation to examine drug-experience induced changes in hedonic encoding in the VP. VP activity was first characterized in adult male Sprague–Dawley rats in response to intraoral infusions of palatable saccharin and unpalatable quinine solutions. Next, rats received 7 daily pairings of saccharin that predicted either a cocaine (20 mg/kg, ip) or saline injection. Finally, the responses to saccharin and quinine were again assessed. Of 109 units recorded in 11 rats that received saccharin–cocaine pairings, 71% of responsive units significantly reduced firing rate during saccharin infusions and 64% increased firing rate during quinine exposure. However, as saccharin came to predict cocaine, and elicited aversive taste reactivity, VP responses changed to resemble quinine. After conditioning, 70% of saccharin-responsive units increased firing rate. Most units that encoded the palatable taste (predominantly reduced firing rate) were located in the anterior VP, while most units that were responsive to aversive tastes were located in the posterior VP. This study reveals an anatomical complexity to the nature of hedonic encoding in the VP.

Comments

Accepted version. Neurobiology of Learning and Memory, Vol. 130 (April 2016): 177-184. DOI. © Elsevier 2016. Used with permission.

NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Learning and Memory. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurobiology of Learning and Memory, Vol. 130, April 2016, DOI.

Available for download on Saturday, April 01, 2017

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