Title

Mediation of Nitrous Oxide Analgesia in Mice by Spinal and Supraspinal Kappa-Opioid Receptors

Document Type

Article

Language

eng

Format of Original

4 p.

Publication Date

1-1990

Publisher

Elsevier

Source Publication

European Journal of Pharmacology

Source ISSN

0014-2999

Original Item ID

doi: 10.1016/0014-2999(90)90158-3

Abstract

Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.

Comments

European Journal of Pharmacology, Vol. 175, No. 1 (January 1990): 97-100. DOI.