Mediation of Nitrous Oxide Analgesia in Mice by Spinal and Supraspinal Kappa-Opioid Receptors
Format of Original
European Journal of Pharmacology
Original Item ID
Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.