Document Type




Format of Original

6 p.

Publication Date




Source Publication

Journal of Neuroendocrinology

Source ISSN


Original Item ID

doi: 10.1111/j.1365-2826.2007.01595.x; PubMed Central: PMCID 2030994


Stressful events before or just after parturition alter the subsequent phenotypical response to stress in a general process termed programming. Hypoxia during the period before and during parturition, and in the postnatal period, is one of the most common causes of perinatal distress, morbidity, and mortality. We have found that perinatal hypoxia (prenatal day 19 to postnatal day 14) augmented the corticosterone response to stress and increased basal corticotrophin-releasing hormone (CRH) mRNA levels in the parvocellular portion of the paraventricular nucleus (PVN) in 6-month-old rats. There was no effect on the levels of hypothalamic parvocellular PVN vasopressin mRNA, anterior pituitary pro-opiomelanocortin or CRH receptor-1 mRNA, or hippocampus glucocorticoid receptor mRNA. We conclude that hypoxia spanning the period just before and for several weeks after parturition programmes the hypothalamic-pituitary-adrenal axis to hyper-respond to acute stress in adulthood, probably as a result of drive from the parvocellular CRH neurones.


Accepted version. Journal of Neuroendocrinology, Vol. 19, No. 11 (November 2007): 907-912. DOI. © Wiley 2007. Used with permission.

This is the peer reviewed version of the following article: "Augmented Hypothalamic Corticotrophin-Releasing Hormone mRNA and Corticosterone Responses to Stress in Adult Rats Exposed to Perinatal Hypoxia," which has been published in final form at here: DOI. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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