Charge Transfer and Oxy Radicals in Antimalarial Action. Quinones, Dapsone Metabolites, Metal Complexes, Iminium Ions, and Peroxides

Authors

J. R. Ames
Michael D. Ryan, Marquette UniversityFollow
D. L. Klayman
P. Kovacic

Document Type

Article

Language

eng

Format of Original

9 p.

Publication Date

1985

Publisher

Elsevier

Source Publication

Free Radical Biology and Medicine

Source ISSN

0891-5849

Original Item ID

DOI: 10.1016/0748-5514(85)90147-3

Abstract

A mechanism of action is proposed that encompasses almost all of the main categories of antimalarial agents: quinones and precursors, dapsone metabolites, metal complexes of thiosemicarbazones and biguanides, iminium-type ions from acridines and quinolines, and peroxides. The toxic effect of the drugs is believed to result from the generation of reactive oxygen radicals that usually arise via charge transfer. Electrochemical studies (reduction potential and reversibility) were performed on a number of these agents. Reduction potentials range from -0.23 to -1.52 V. It is likely that the in vivo values are appreciably more positive in certain cases.

Comments

Free Radical Biology and Medicine, Vol. 1 (1985): 353-361. DOI.

Recommended Citation

Ames, J. R.; Ryan, Michael D.; Klayman, D. L.; and Kovacic, P., "Charge Transfer and Oxy Radicals in Antimalarial Action. Quinones, Dapsone Metabolites, Metal Complexes, Iminium Ions, and Peroxides" (1985). Chemistry Faculty Research and Publications. 438.
https://epublications.marquette.edu/chem_fac/438