Cyclic Voltammetry of Quinolinium Salts and Related Compounds: Correlation with Structure and Anticancer Activity

Authors

Philip Walter Crawford, Marquette UniversityFollow
William O. Foye, Massachusetts College of Pharmacy and Allied Health Sciences
Michael D. Ryan, Marquette UniversityFollow
Peter Kovacic, University of Wisconsin - MilwaukeeFollow

Document Type

Article

Language

eng

Format of Original

4 p.

Publication Date

6-1987

Publisher

Wiley

Source Publication

Journal of Pharmaceutical Sciences

Source ISSN

0022-3549

Abstract

Cyclic voltammetry data were obtained for 12 salts of quinolines, one pyridine, and one open-chain imine which possess varying degrees of anticancer activity. The structural features include sidechain bis(2-methylthio)vinyl, 2-methylthio-2-aminovinyl, dithioacetic acid, 2-quinolylvinyl, 2-styrylvinyl, and guanidine sulfide functionalities. Reduction potentials ranged from −0.43 to −1.08 V. The electrochemical results are correlated with structure. A possible mechanism of anticancer action is addressed.

Comments

Journal of Pharmaceutical Sciences, Vol. 76, No. 6 (June 1987): 481-484. DOI.

Recommended Citation

Crawford, Philip Walter; Foye, William O.; Ryan, Michael D.; and Kovacic, Peter, "Cyclic Voltammetry of Quinolinium Salts and Related Compounds: Correlation with Structure and Anticancer Activity" (1987). Chemistry Faculty Research and Publications. 498.
https://epublications.marquette.edu/chem_fac/498