Document Type

Article

Language

eng

Publication Date

9-2015

Publisher

Elsevier

Source Publication

Analytical Biochemistry

Source ISSN

1096-0309

Original Item ID

DOI: 10.1016/j.ab.2015.06.003

Abstract

Acute myocardial infarction (AMI) is the leading cause of death among cardiovascular diseases. Among the numerous attempts to develop coronary marker concepts into clinical strategies, cardiac troponin is known as a specific marker for coronary events. The cardiac troponin concentration level in blood has been shown to rise rapidly for 4–10 days after onset of AMI, making it an attractive approach for a long diagnosis window for detection. The extremely low clinical sensing range of cardiac troponin levels consequently makes the methods of detection highly sensitive. In this review, by taking into consideration optical methods applied for cardiac troponin detection, we discuss the most commonly used methods of optical immunosensing and provide an overview of the various diagnostic cardiac troponin immunosensors that have been employed for determination of cardiac troponin over the last several years.

Comments

Accepted version. Analytical Biochemistry, Vol. 485 (September 15, 2015): 1-10. DOI. © 2015 Elsevier Inc. Used with permission.

NOTICE: this is the author’s version of a work that was accepted for publication in Analytical Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Analytical Biochemistry, Vol. 485 (September 15, 2015): 1-10. DOI.

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