Proceedings of the International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition
Multi-echo-time echo planar image acquisitions allow for the consideration of BOLD related T2* decay. Studies which have included single-shot, multi-echo acquisitions to calculate T2* have been shown to yield activations which are appropriately localized when compared to proton spin density images calculated from the same T2* weighted images (1), allowing the separation of BOLD T2* effects from other effects which arise in the proton spin density images. However, such pulse sequences require the acquisition of additional data in each shot, reducing the available slice coverage for a given TR. In this abstract, we present a method for the statistical analysis of multi-echo time fMRI data, and apply it to data acquired in a pulse sequence where the echo time is shifted by 20 ms for alternating TRs, thereby allowing the same slice coverage as standard, single echo data acquisitions.