Indomethacin Preserves Muscle Mass and Reduces Levels of E3 Ligases and TNF Receptor Type 1 in the Gastrocnemius Muscle of Tumor-Bearing Mice
Document Type
Article
Language
eng
Publication Date
2-2005
Publisher
Wiley
Source Publication
Research in Nursing and Health
Source ISSN
0160-6891
Original Item ID
DOI: 10.1002/nur.20057
Abstract
Tumor-induced skeletal muscle wasting involves tumor necrosis factor (TNF) and the ubiquitin-proteasome pathway of muscle protein degradation. In this study, growth of the colon-26 adenocarcinoma in mice was associated with diminished gastrocnemius muscle mass and increased muscle levels of actin, ubiquitin-conjugated proteins, free ubiquitin, E3 ubiquitin ligases, and the type 1 TNF receptor (TNFR1). Indomethacin at 1 or 5 mg/kg/day reduced tumor growth and muscle levels of TNFR1. However, only the 5 mg dose of indomethacin reduced muscle wasting and muscle levels of the E3 ligases and actin. These data suggest that the beneficial effects of indomethacin in the treatment of tumor-induced skeletal muscle wasting may involve inhibition of TNF- and ubiquitin-mediated pathways of muscle protein degradation. These data also demonstrate that E3 ligases, which are involved in disuse atrophy, also are associated with tumor-induced skeletal muscle wasting. © 2004 Wiley Periodicals, Inc. Res Nurs Health 28:56–66, 2005
Recommended Citation
Hitt, Andrew; Graves, Erin; and McCarthy, Donna O., "Indomethacin Preserves Muscle Mass and Reduces Levels of E3 Ligases and TNF Receptor Type 1 in the Gastrocnemius Muscle of Tumor-Bearing Mice" (2005). College of Nursing Faculty Research and Publications. 191.
https://epublications.marquette.edu/nursing_fac/191
Comments
Journal in Nursing and Health, Vol. 28, No. 1 (February 2005): 56-66. DOI.
Donna McCarthy was affiliated with the National Institute of Nursing Research at the time of publication.