Indomethacin and Ibuprofen Preserve Gastrocnemius Muscle Mass in Mice Bearing the Colon26 Adenocarcinoma

Document Type

Article

Language

eng

Format of Original

11 p.

Publication Date

6-2004

Publisher

Wiley

Source Publication

Research in Nursing and Health

Source ISSN

0160-6891

Original Item ID

doi: 10.1002/nur.20019; Shelves: RT1 .R48x Raynor Memorial Periodicals

Abstract

Skeletal muscle wasting is a prominent feature of cancer cachexia and involves decreased muscle protein synthesis and increased activity of the ubiquitin-proteasome pathway of protein degradation. We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice. Ibuprofen increased the soluble protein content of the muscle without affecting muscle levels of phosphorylated p70 S6 kinase, a ribosomal kinase involved in protein synthesis. Paradoxically, indomethacin increased levels of ubiquitin-conjugated proteins. Further study is needed to understand the mechanism of action by which indomethacin and ibuprofen preserve body weight and muscle mass in the tumor-bearing mice. The data suggest that ibuprofen may have beneficial effects in the treatment of cancer cachexia. © 2004 Wiley Periodicals, Inc. Res Nurs Health 27:174–184, 2004

Comments

Research in Nursing and Health, Vol. 27, No. 3 (June 2004): 174-184. DOI.

Donna McCarthy was affiliated with the National Institute of Nursing Research and the University of Wisconsin - Madison at the time of publication.

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