Association Between Sedentary Time and Quality of Life From the Osteoarthritis Initiative: Who Might Benefit Most From Treatment?

Authors

Daniel Pinto, Marquette UniversityFollow
Jing Song, Northwestern University
Jungwha Lee, Northwestern University
Rowland W. Chang, Northwestern UniversityFollow
Pamela A. Semanik, Rush UniversityFollow
Linda S. Ehrlich-Jones, Shirley Ryan AbilityLab
Christine A. Pellegrini, University of South CarolinaFollow
Dorothy D. Dunlop, Northwestern University

Document Type

Article

Language

eng

Publication Date

12-2017

Publisher

Elsevier

Source Publication

Archives of Physical Medicine and Rehabilitation

Source ISSN

0003-9993

Abstract

Objective

To investigate the relationship between sedentary behavior and quality-adjusted life years (QALYs) among participants in the Osteoarthritis Initiative.

Design

Longitudinal, observational design.

Setting

Osteoarthritis Initiative cohort.

Participants

Individuals (N=1794) from a prospective, multicenter longitudinal cohort were classified into quantile groups based on average daily sedentary time (most sedentary, quartile 1 [Q1] ≥11.6h; 10.7h≤ Q2

Interventions

Not applicable.

Main Outcome Measures

Individual QALYs were estimated over 2 years from the area under the curve of health-related utility scores derived from the Medical Outcomes Study 12-Item Short-Form Health Survey versus time. The relationship between baseline sedentary behavior and median 2-year QALYs was estimated using quantile regression adjusted for socioeconomic factors and body mass index.

Results

Lower QALYs over 2 years were more frequently found among the most sedentary (Q1, median 1.59), and QALYs increased as time spent in baseline sedentary behavior decreased (median QALYs for Q2, 1.64; Q3, 1.65; Q4, 1.65). The relationship of sedentary time and median QALY change was only significant for the most sedentary Q1 group, where an additional hour of sedentary behavior significantly reduced QALYs by −.072 (95% confidence interval, −.121 to −.020).

Conclusions

Our findings suggest that individuals with the most extreme sedentary profiles may be vulnerable to additional losses of quality of life if they become more sedentary. Targeting these individuals to decrease sedentary behavior has the potential to be cost-effective.

Comments

Accepted version. Archives of Physical Medicine and Rehabilitation, Vol. 98, No. 12 (December 2017): 2485-2490. DOI. © 2017 Elsevier B.V. Used with permission.

Daniel Pinto was affiliated with Northwestern University at the time of publication.

Recommended Citation

Pinto, Daniel; Song, Jing; Lee, Jungwha; Chang, Rowland W.; Semanik, Pamela A.; Ehrlich-Jones, Linda S.; Pellegrini, Christine A.; and Dunlop, Dorothy D., "Association Between Sedentary Time and Quality of Life From the Osteoarthritis Initiative: Who Might Benefit Most From Treatment?" (2017). Physical Therapy Faculty Research and Publications. 145.
https://epublications.marquette.edu/phys_therapy_fac/145