Document Type

Article

Language

eng

Format of Original

12 p.

Publication Date

10-1-2013

Publisher

Elsevier

Source Publication

Respiratory Physiology & Neurobiology

Source ISSN

1569-9048

Original Item ID

doi: 10.1016/j.resp.2013.06.003; PubMed Central: PMCID 4338573

Abstract

Herein we compare the effects of perturbations in the Kölliker–Fuse nucleus (KFN) and the lateral (LPBN) and medial (MPBN) parabrachial nuclei on the coordination of breathing and swallowing. Cannula was chronically implanted in goats through which ibotenic acid (IA) was injected while awake. Swallows in late expiration (E) always reset while swallows in early inspiration (I) never reset the respiratory rhythm. Before cannula implantation, all other E and I swallows did not reset the respiratory rhythm, and had small effects on E and I duration and tidal volume (VT). However, after cannula implantation in the MPBN and KFN, E and I swallows reset the respiratory rhythm and increased the effects on I and E duration and VT. Subsequent injection of IA into the KFN eliminated the respiratory phase resetting of swallows but exacerbated the effects on I and E duration and VT. We conclude that the KFN and to a lesser extent the MPBN contribute to coordination of breathing and swallowing.

Comments

Accepted version. Respiratory Physiology & Neurobiology, Vol. 189, No. 1 (October 1, 2013): 10-21. DOI. © 2013 Elsevier. Used with permission.

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