Document Type

Conference Proceeding

Language

eng

Format of Original

1 p.

Publication Date

2012

Publisher

MIT Press

Source Publication

Journal of Cognitive Neuroscience

Source ISSN

0898-929X

Abstract

Apolipo-protein E (APOE) ?4 allele carriers demonstrate greater risk for cognitive decline and Alzheimer's disease than non-carriers. However, factors associated with risk of decline among APOE ?4 carriers are not well-known. In this longitudinal study, we investigated whether discrete aspects of baseline episodic memory performance and structural (sMRI) and function (fMRI) magnetic resonance imaging were associated with cognitive decline in older APOE ?4 carriers and non-carriers. Seventy-eight healthy older adults underwent cognitive testing at baseline and after 18 months, baseline serum APOE genotyping, manually-traced hippocampal volume measurement from sMRI, and task-activated fMRI. Cognitive decline was defined as a one SD or greater reduction from baseline on at least one of three cognitive measures at follow-up (Rey Auditory Verbal Learning Test [AVLT] Delayed Recall and Trials 1-5 Sum, Mattis Dementia Rating Scale-2 Total Score). Declining APOE ?4 carriers (n=14) exhibited reduced hippocampal volume (p

Comments

Published version. Published as part of the proceedings of the conference, 2012 Annual Meeting of the Cognitive Neuroscience Society, 2012: 116. Publisher Link. © 2012 Massachusetts Institute of Technology Press (MIT Press). Used with permission.

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