Location
Schroeder Complex Hartman Center
Start Date
26-3-2010 10:00 AM
Document Type
Event
End Date
26-3-2010 10:30 AM
Abstract
Language Outcome after Left Temporal Anterior Lobectomy in Patients with Discordant Functional Magnetic Resonance Imaging and Intracarotid Sodium Amobarbital Testing Results Rationale: Previous research has examined concordance rates between Wada and fMRI language lateralization indices (LIs) and has yielded variable results with limited post-surgical language outcome data. Therefore, additional evidence of the concurrent and predictive validity of fMRI LIs is needed. We will calculate Wada/fMRI LI concordance rates in the largest sample to date, investigate predictors of discordance and examine the ability of each procedure to predict language outcome in discordant cases. Methods: A consecutive series of 229 presurgical epilepsy patients who underwent Wada testing and fMRI will be included in the study. Wada LIs (% correct inject right –% correct inject left condition) were calculated based on performance on comprehension, naming, repetition and reading language tasks. fMRI LIs ((L-R)/(L+R) where L = number of activated left hemisphere voxels and R = number of activated right hemisphere voxels) were calculated for four ROIs using a published semantic decision/tone decision task. Discordance will be determined using a difference score of .50. Regression analyses will be performed to investigate factors that are predictive of discordance and the predictive value of Wada and fMRI in discordant cases. Results: Available by conference date. Conclusions: We hypothesize a discordance rate of approximately 1 in 10. We hypothesize predictors of discordance may be posterior cerebral artery filling, crossflow ratings, abnormal vasculature, duration of drug effect, fMRI behavioral performance and activation threshold, motion artifacts, MTS, and IQ.
Included in
Language Outcome after Left Anterior Temporal Lobectomy in Patients with Discordant Functional Magnetic Resonance Imaging and Intracarotid Sodium Amobarbital Testing Results
Schroeder Complex Hartman Center
Language Outcome after Left Temporal Anterior Lobectomy in Patients with Discordant Functional Magnetic Resonance Imaging and Intracarotid Sodium Amobarbital Testing Results Rationale: Previous research has examined concordance rates between Wada and fMRI language lateralization indices (LIs) and has yielded variable results with limited post-surgical language outcome data. Therefore, additional evidence of the concurrent and predictive validity of fMRI LIs is needed. We will calculate Wada/fMRI LI concordance rates in the largest sample to date, investigate predictors of discordance and examine the ability of each procedure to predict language outcome in discordant cases. Methods: A consecutive series of 229 presurgical epilepsy patients who underwent Wada testing and fMRI will be included in the study. Wada LIs (% correct inject right –% correct inject left condition) were calculated based on performance on comprehension, naming, repetition and reading language tasks. fMRI LIs ((L-R)/(L+R) where L = number of activated left hemisphere voxels and R = number of activated right hemisphere voxels) were calculated for four ROIs using a published semantic decision/tone decision task. Discordance will be determined using a difference score of .50. Regression analyses will be performed to investigate factors that are predictive of discordance and the predictive value of Wada and fMRI in discordant cases. Results: Available by conference date. Conclusions: We hypothesize a discordance rate of approximately 1 in 10. We hypothesize predictors of discordance may be posterior cerebral artery filling, crossflow ratings, abnormal vasculature, duration of drug effect, fMRI behavioral performance and activation threshold, motion artifacts, MTS, and IQ.