31P Nuclear Magnetic Resonance Spectroscopy of Bone Mineral for Evaluation of Osteoporosis

Ravi Srinivisan, Marquette University

Abstract

A number of simulations were done on the computer for the author to gain insight into N M R spectroscopy. A detailed N M R study of eight human vertebral bodies was done using the Nicolet NT-1S0 spectrometer. Radiofrequency coils were designed and built to obtain in-vivo quantification of bone mineral in human fingers, palm and wrist. Finally, in-vitro spectra of canine skeletal muscle and canine bone marrow were obtained to study the possible signal interferences present if any, may have on in-vivo bone mineral quantification.