Document Type




Format of Original

6 p.

Publication Date



Institute of Electrical and Electronics Engineers

Source Publication

IEEE Transactions on Biomedical Engineering

Source ISSN


Original Item ID

doi: 10.1109/TBME.2008.925695


The repeatability and resolution of the clinical gold standard of vascular assessment, the ankle-brachial index (ABI), was compared to that of a new device that dynamically assesses tissue perfusion during external loading utilizing laser Doppler flowmetry. Eight subjects of varying levels of vascular impairment were tested in successive weeks using two different sites on the subject's posterior calf. These new measures included the perfusion decrease as well as the unloading delay during cyclic loading. Some new dynamic tissue perfusion measures demonstrated comparable levels of reproducibility with the ABI (e.g., 10%-20%). Only the unloading delay showed potentially enhanced resolution over ABI measures. The perfusion decrease showed little resolution, and the remaining parameters exhibited too great variability (25%-90%). The unloading delay associated with the reperfusion response during cyclic loading displayed the greatest combination of reproducibility and differentiation between subject groups of varying levels of vascular impairment. The preliminary results of this pilot study were also used to estimate sample sizes necessary to detect possible significant (P


Accepted version. IEEE Transactions on Biomedical Engineering, Vol. 55, No. 12 (December 2008): 2786-2791. DOI. © 2008 Institute of Electrical and Electronic Engineers (IEEE). Used with permission.

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