SPECT/Micro-CT Imaging of Bronchial Angiogenesis in a Rat

Document Type

Contribution to Book



Format of Original

5 p.

Publication Date




Source Publication

Small Animal SPECT Imaging

Source ISSN


Original Item ID

DOI: 10.1007/0-387-25294-0_23


The bronchial circulation provides the lung with an oxygenated blood supply, derived from the aorta, whose primary purpose under normal conditions is thought to be nourishment of the airway walls +Guyton, 1996-. However,the study of the bronchial circulation and its development is particularly important with regard to lung tumors whose blood supply is via the bronchial circulation rather than the pulmonary circulation +Hirsch, 2001, Ohta, 2002-. Thus, we have developed a rat model of bronchial circulation angiogenesis,induced by complete occlusion of the left pulmonary artery. We have been observing the resulting perfusion changes in the left lung using dual-modality SPECT/micro-CT imaging. The initial objective of this study is to develop the necessary imaging system, protocol, and analysis methods for determining the time course of this angiogenesis, with the subsequent goal of using this approach to study the particular angiogenic mechanisms that might be involved.


"SPECT/Micro-CT Imaging of Bronchial Angiogenesis in a Rat," in Small Animal SPECT Imaging. Eds. Matthew A. Kupinski and Harrison H. Barrett. New York: Springer US, 2005, 273-277. DOI.

Anne V. Clough was also affiliated with the Zablocki VA Medical Center at time of publication.

Robert C. Molthen was affiliated with the Zablocki VA Medical Center and the Medical College of Wisconsin at time of publication.