Document Type

Conference Proceeding



Format of Original

16 p.

Publication Date



Institute of Electrical and Electronics Engineers (IEEE)

Source Publication

Proceedings of the IEEE

Source ISSN


Original Item ID

DOI: 10.1109/JPROC.2006.871771


Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are affected by lung injury and disease. The indicator dilution method was used to study the activity of redox processes within the lung. A steady-state model of the data was constructed and used to show that pulmonary endothelial cells may play an important role in reducing redox active compounds and that those reduction rates can be altered with oxidative stress induced by exposure to high oxygen environments. In addition, a morphometric model of the pulmonary vasculature was described and used to detect, describe,and predict changes in vascular morphology that occur in response to chronic exposure to low-oxygen environments, a common model of pulmonary hypertension. Finally, the model was used to construct simulated circulatory networks designed to aid in evaluation of competing hypotheses regarding the relative contribution of various morphological and biomechanical changes observed with hypoxia. These examples illustrate the role of mathematical modeling in the integration of the emerging metabolic, hemodynamic, and morphometric databases.


Accepted version. Published as part of the Proceedings of the IEEE, Vol. 94, No. 4 (April 2006): 753 - 768. DOI. © 2006 Institute of Electrical and Electronics Engineers (IEEE). Used with permission.

Robert C. Molthen was affiliated with the Medical College of Wisconsin at time of publication.