Clinical Correlates of High Cervical Fractional Anisotropy in Acute Cervical Spinal Cord Injury
Format of Original
Original Item ID
Objective: Fractional anisotropy (FA) of the high cervical cord (C1-C2), rostral to the injury site, correlates with upper limb function in patients with chronic cervical spinal cord injury (SCI). In acute cervical SCI, this relationship has not been investigated. The objective of this study was to identify functional correlates of FA of the high cervical cord in a series of patients with acute cervical SCI.
Methods: Traumatic cervical SCI patients who underwent presurgical cervical spine diffusion tensor imaging at our institution were reviewed for this study. FA of the whole cord as well as the lateralcorticospinal tracts (CSTs) was calculated on axial images from C1-C2. Upper limb motor (C5-T1) and sensory (C2-T1) function scores were extracted from the admission American Spinal Injury Association (ASIA) examinations. Correlation analysis for FA with ASIA examinations was performed using a Pearson correlation.
Results: Twelve subjects (9 men, 3 women; mean age 54.7 ± 4.0 years) underwent cervical spine diffusion tensor imaging at a mean duration of 3.6 ± 0.9 days postinjury. No patient had cord compression or intramedullary T2-weighted hyperintensities within the C1-C2 segments. FA correlated with upper limb motor score (whole cord: r = 0.59, P = .04; CST: 0.67, P = .01) and the ASIA grade (whole cord: r = 0.61, P = .03; CST: r = 0.71, P = .009). No correlation was found between FA and sensory scores.
Conclusions: FA of the whole cervical cord as well as the CST, rostral to the injury site, is associated with preserved upper limb motor function as well as superior ASIA grades after acute cervical SCI. FA of the high cervical cord is a potential biomarker of neural injury after acute cervical SCI.
Vedantam, Aditya; Eckardt, Gerald; Wang, Marjorie C.; Schmit, Brian D.; and Kurpad, Shekar N., "Clinical Correlates of High Cervical Fractional Anisotropy in Acute Cervical Spinal Cord Injury" (2015). Biomedical Engineering Faculty Research and Publications. 425.
Accepted version. World Neurosurgery, Vol 83, No. 5 (May 2015): 824-828. DOI. © 2015 Elsevier, Inc. Used with permission.
NOTICE: this is the author’s version of a work that was accepted for publication in World Neurosurgery. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in World Neurosurgery, Vol 83, No. 5 (May 2015): 824-828. DOI.