Title

Evaluation of 70/30 poly (l-lactide-co-d,l-lactide) for use as a resorbable interbody fusion cage

Document Type

Article

Language

eng

Publication Date

11-2002

Publisher

American Association of Neurological Surgeons

Source Publication

Journal of Neurosurgery: Spine

Source ISSN

1547-5654

Abstract

Object. Titanium lumbar interbody spinal fusion devices are reported to be 90% effective in cases requiring single-level lumbar interbody arthrodesis, although radiographic determination of fusion has been debated.

Methods. Using blinded radiographic, biomechanical, histological, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(l-lactide-co-d,l-lactide) interbody fusion device packed with autograft or recombinant human bone morphogenetic protein—2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologically confirmed fusion was demonstrated at 3 months to 24 months postimplantation. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.

Conclusions. Use of this material in interbody fusion may be a viable alternative to metals.

Comments

Journal of Neurosurgery: Spine, Vol. 97, No. 4 (November, 2002): <423-432>. DOI.

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