Evaluation of 70/30 poly (l-lactide-co-d,l-lactide) for Use as a Resorbable Interbody Fusion Cage
American Association of Neurological Surgeons
Journal of Neurosurgery: Spine
Object. Titanium lumbar interbody spinal fusion devices are reported to be 90% effective in cases requiring single-level lumbar interbody arthrodesis, although radiographic determination of fusion has been debated.
Methods. Using blinded radiographic, biomechanical, histological, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(l-lactide-co-d,l-lactide) interbody fusion device packed with autograft or recombinant human bone morphogenetic protein—2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologically confirmed fusion was demonstrated at 3 months to 24 months postimplantation. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.
Conclusions. Use of this material in interbody fusion may be a viable alternative to metals.