Explant Analysis of Total Disc Replacement

Authors

Paul A. Anderson, University of Wisconsin
Steven M. Kurtz, Drexel University
Jeffrey M. Toth, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

6-2006

Publisher

Elsevier

Source Publication

Seminars in Spine Surgery

Source ISSN

1040-7383

Abstract

Explant analysis of human disc prostheses allow early evaluation of the host response to the prosthesis and the response of the prosthesis from the host. Furthermore, early predictions of failure and wear can be obtained. Thus far, about 2-3% of disc prostheses have been removed. Observed wear patterns are similar to that of appendicular prostheses including abrasions/scratching, burnishing, surface deformation, fatigue, and embedded debris. Chemically the polymeric components have shown little degradation in short-term implantation. In metal on metal prostheses the histologic responses consist of large numbers of metallic particles with occasional macrophages and giant cells. Only rare cases of significant inflammatory response from polymeric debris have been seen.

Comments

Accepted version. Seminars in Spine Surgery, Vol. 18, No. 2 (June 2006): 109-116. DOI. © 2006 Elsevier B.V. Used with permission.

Recommended Citation

Anderson, Paul A.; Kurtz, Steven M.; and Toth, Jeffrey M., "Explant Analysis of Total Disc Replacement" (2006). Biomedical Engineering Faculty Research and Publications. 555.
https://epublications.marquette.edu/bioengin_fac/555