Cellular Responses to Whitlockite

Authors

L. M. Ryan, Medical College of Wisconsin
H. S. Cheung, Medical College of Wisconsin
R. Z. LeGeros, New York University
I. V. Kurup, Medical College of Wisconsin
Jeffrey M. Toth, Marquette UniversityFollow
P. R. Westfall, Medical College of Wisconsin
G. M. McCarthy, Medical College of Wisconsin

Document Type

Article

Language

eng

Publication Date

11-1999

Publisher

Springer

Source Publication

Calcified Tissue International

Source ISSN

0171-967X

Abstract

Whitlockite crystals have been observed in both degenerating and normal articular cartilages. To determine their potential for inducing cartilage degeneration, we studied their ability to induce mitogenesis and synthesis and secretion of metalloproteases in vitro. Whitlockite crystals were found to stimulate cell proliferation and to stimulate synthesis and secretion of stromelysin and collagenase. However, they were less stimulatory than crystals that contained calcium (Ca) and phosphate without magnesium substitution for Ca. Whitlockite crystals elicit biologic cellular responses that suggest potential pathogenicity in arthritis, but are less potent than Ca phosphate crystals without magnesium.

Comments

Cellular Responses to Whitlockite, Vol. 65, No. 5 (November 1999): 374-377. DOI.

Jeffrey M. Toth was affiliated with the Medical College of Wisconsin at the time of publication.

Recommended Citation

Ryan, L. M.; Cheung, H. S.; LeGeros, R. Z.; Kurup, I. V.; Toth, Jeffrey M.; Westfall, P. R.; and McCarthy, G. M., "Cellular Responses to Whitlockite" (1999). Biomedical Engineering Faculty Research and Publications. 564.
https://epublications.marquette.edu/bioengin_fac/564