Recent Advances in Intraoperative Lumpectomy Margin Assessment for Breast Cancer

Document Type

Article

Publication Date

9-2022

Publisher

Wiley

Source Publication

Current Breast Cancer Reports

Source ISSN

1943-4588

Original Item ID

DOI: 10.1007/s12609-022-00451-5

Abstract

Purpose of Review

Successful breast-conserving surgery is predicated on achieving negative margins (no tumor on ink) at the time of initial surgery. This review will summarize currently available intraoperative margin assessment options and then focus on the most promising intraoperative margin assessment modalities that a breast surgeon will likely see in the next decade.

Recent Findings

Current intraoperative margin assessment options vary in performance, turn-around time, and necessary resources. There are an extensive number of different emerging technologies in varying stages of development, including automated pathologic assessment, traditional and novel imaging modalities, optical imaging, spectroscopy, fluorescence-based imaging, and molecular and nanoparticle-based imaging.

Summary

There is an unmet need for more effective technology to accurately and quickly determine lumpectomy margin status intraoperatively without requiring significant or specialized resources. In addition, this technology must be low-cost, easy-to-use, and not disruptive to operating room workflow.

Comments

Current Breast Cancer Reports, Vol. 14 (September 2022): 93-102. DOI.

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