Title

Evidence for a Second Type of Fibril Branch Point in Fibrin Polymer Networks, the Trimolecular Junction

Document Type

Article

Publication Date

9-1-1993

Publisher

American Society of Hematology

Source Publication

Blood

Source ISSN

0006-4971

Original Item ID

DOI: 10.1182/blood.V82.5.1517.1517

Abstract

Fibrin molecules polymerize to double-stranded fibrils by intermolecular end-to-middle domain pairing of complementary polymerization sites, accompanied by fibril branching to form a clot network. Mass/length measurements on scanning transmission electron microscopic images of fibrils comprising branch points showed two types of junctions. Tetramolecular junctions occur when two fibrils converge, creating a third branch with twice the mass/length of its constituents. Newly recognized trimolecular junctions have three fibril branches of equal mass/length, and occur when an extraneous fibrin molecule initiates branching in a propagating fibril by bridging across two unpaired complementary polymerization sites. When trimolecular junctions predominate, clots exhibit nearly perfect elasticity.

Comments

Blood, Vol. 83, No. 5 (September 1, 1993): 1517-1521. DOI.

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