Mediation of Nitrous Oxide Analgesia in Mice by Spinal and Supraspinal Kappa-Opioid Receptors
Format of Original
European Journal of Pharmacology
Original Item ID
Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.
Quock, Raymond M.; Best, J. A.; Chen, D. C.; Vaughn, Linda K.; Portoghese, P. S.; and Takemori, A. E,, "Mediation of Nitrous Oxide Analgesia in Mice by Spinal and Supraspinal Kappa-Opioid Receptors" (1990). Biomedical Sciences Faculty Research and Publications. 70.