Mediation of Nitrous Oxide Analgesia in Mice by Spinal and Supraspinal Kappa-Opioid Receptors

Authors

Raymond M. Quock, Marquette UniversityFollow
J. A. Best
D. C. Chen
Linda K. Vaughn, Marquette UniversityFollow
P. S. Portoghese
A. E, Takemori

Document Type

Article

Language

eng

Format of Original

4 p.

Publication Date

1-1990

Publisher

Elsevier

Source Publication

European Journal of Pharmacology

Source ISSN

0014-2999

Original Item ID

doi: 10.1016/0014-2999(90)90158-3

Abstract

Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.

Comments

European Journal of Pharmacology, Vol. 175, No. 1 (January 1990): 97-100. DOI.

Recommended Citation

Quock, Raymond M.; Best, J. A.; Chen, D. C.; Vaughn, Linda K.; Portoghese, P. S.; and Takemori, A. E,, "Mediation of Nitrous Oxide Analgesia in Mice by Spinal and Supraspinal Kappa-Opioid Receptors" (1990). Biomedical Sciences Faculty Research and Publications. 70.
https://epublications.marquette.edu/biomedsci_fac/70