Document Type

Article

Language

eng

Publication Date

6-28-2019

Publisher

American Chemical Society

Source Publication

Journal of the American Chemical Society

Source ISSN

0002-7863

Abstract

The syntheses and O2 reactivities of active-site models of cobalt-substituted ring-cleaving dioxygenases are presented. The pentacoordinate cobalt(II)-aminophenolate complex, [Co(TpMe2)(tBu2APH)], gives rise to two distinct dioxygen adducts at reduced temperatures. The first is a paramagnetic (S = 1/2) cobalt(III)-superoxo species that was characterized with spectroscopic and computational techniques. The identity of the second Co/O2 adduct was elucidated by X-ray crystallography, which revealed an unprecedented cobalt(III)-alkylperoxo structure generated by O2 addition to the metal ion and ligand. These results provide synthetic precedents for proposed intermediates in the catalytic cycles of O2-activating cobalt enzymes.

Comments

Accepted version. Journal of the American Chemical Society, Vol. 114, No. 28 (June 28, 2019): 10984-10987. DOI. © 2019 American Chemical Society. Used with permission.

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