Recent Applications of the Simple Hydrocarbon Cyclooctatetrene as a Starting Material for Complex Molecule Synthesis
Mini-Reviews in Organic Chemistry
Cyclooctatetraene [COT], a simple non-aromatic cyclic polyene, is capable of undergoing a variety of oxidation and cycloaddition reactions to afford polycyclic structures. In addition, complexation of COT or the cycloaddition products with transition metals facilitates bond formation. Recent developments in the reactivity of COT and application to the synthesis of naturally occurring and non-naturally occurring compounds is reviewed.
Glaeske, Kevin W. and Donaldson, William, "Recent Applications of the Simple Hydrocarbon Cyclooctatetrene as a Starting Material for Complex Molecule Synthesis" (2012). Chemistry Faculty Research and Publications. 199.
Accepted version. Mini-Reviews in Organic Chemistry, Volume 9, Number 1, pp 31-43 (February 2012). DOI: 10.2174/157019312799079983. © 2012 Bentham Science Publishers. Used with permission.