A novel approach to pattern silanized-biomolecules directly onto glass (SiOx) substrates via Dip-Pen nanolithography (DPN) and microcontact printing (μCP) is presented. Subsequent hybridization reactions of DPN patterned silanized-DNA with its complementary strands provide “proof-of-concept” that the patterned oligonucleotides maintain their biological activities. The fabrication strategy does not require premodification of substrates and offers a cheap and robust way to immobilize molecules on electronically important semiconductor surfaces.
Nyamjav, Dorjderem and Holz, Richard C., "Direct Patterning of Silanized-Biomolecules on Semiconductor Surfaces" (2010). Chemistry Faculty Research and Publications. 283.
ADA Accessible Version
Accepted version. Langmuir, Vol. 26, No. 23 (2010): 18300-18302. DOI. © 2010 American Chemical Society Publications. Used with permission.
Richard C. Holz was affiliated with Loyola University-Chicago at the time of publication.