Angewandte Chemie International Edition
Consequences of alternative H-bonding: Raman spectra of oxygenated intermediates of Nanodisc-incorporated human CYP17 in the presence of natural substrates (pregnenolone and progesterone) directly confirm that substrate structure effectively alters hydrogen-bonding interactions with the critical Fe–O–O fragment and dictates its predisposition for one of two alternative reaction pathways. Such substrate control has profound physiological implications.
Gregory, Michael; Mak, Piotr J.; Sligar, Stephen G.; and Kincaid, James R., "Differential Hydrogen Bonding in Human CYP17 Dictates Hydroxylation versus Lyase Chemistry" (2013). Chemistry Faculty Research and Publications. 374.
Accepted version. Angewandte Chemie International Edition, Vol. 52, No. 20 (May 10, 2013): 5342-5345. DOI. © 2013 Wiley-VCH Verlag. Used with permission.