Format of Original
American Chemical Society
Journal of Organic Chemistry
Original Item ID
The cationic ruthenium catalyst Ru3(CO)12/NH4PF6 was found to be highly effective for the intermolecular coupling reaction of pyrroles and terminal alkynes to give gem-selective α-vinylpyrroles. The carbon isotope effect on the α-pyrrole carbon and the Hammett correlation from a series of para-substituted N-arylpyrroles (ρ = −0.90) indicate a rate-limiting C−C bond formation step of the coupling reaction.
Gao, Ruili and Yi, Chae S., "Regioselective Formation of α-Vinylpyrroles from the Ruthenium-Catalyzed Coupling Reaction of Pyrroles and Terminal Alkynes Involving C–H Bond Activation" (2010). Chemistry Faculty Research and Publications. 385.