Electrochemistry of Cyclic α-imino Carboxylates and their Metal Complexes: Correlation with Physiological Activity

Authors

Peter Kovacic, University of Wisconsin - Milwaukee
William J. Popp, University of Wisconsin - Milwaukee
Jack W. Timberlake, University of New Orleans
Michael D. Ryan, Marquette UniversityFollow

Document Type

Article

Language

eng

Format of Original

10 p.

Publication Date

1989

Publisher

Elsevier

Source Publication

Chemico-Biological Interactions

Source ISSN

0009-2797

Abstract

Cyclic voltammetry data were obtained for Δ¹-pyrroline-2-carboxylate, Δ³-thiazoline-4-carboxylate, Δ²-thiazoline-2-carboxylate and their complexes with Cu(II), Fe(III), and Fe(II). The free ligands were reduced at about −0.35 V and were oxidized in the range of 0.42–0.52 V. Complexing the imine carboxylates with metal ions produces reduction and oxidation in the ranges of 0.05–0.37 V and 0.52–0.74 V, respectively. Prior reports show that these ligands take part in various biological functions. We propose that electron transfer may be involved in some aspects of the physiological activity. The captodative effect can be applied.

Comments

Chemico-Biological Interactions, Vol. 69, No. 2-3 (1989): 235-244. DOI.

Recommended Citation

Kovacic, Peter; Popp, William J.; Timberlake, Jack W.; and Ryan, Michael D., "Electrochemistry of Cyclic α-imino Carboxylates and their Metal Complexes: Correlation with Physiological Activity" (1989). Chemistry Faculty Research and Publications. 492.
https://epublications.marquette.edu/chem_fac/492