Document Type

Article

Language

eng

Publication Date

11-1986

Publisher

Cognizant Communication Corporation

Source Publication

Anti-Cancer Drug Design

Source ISSN

0266-9536

Abstract

The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm. Electrochemical studies were performed with some of the main types of agents: iminium ions (adenine iminium from alkylating species, iminium metabolite of 6-mercaptopurine, nitidine, other polynuclear iminiums) and metal complexes (Pt(II)diaquodiammine-guanosine, copper salicylaldoximes). Reduction potentials ranged from -0.4 to -1.2 V. Literature data for quinones are presented and radiation is discussed. Based on the theoretical framework, a rationale is offered for the carcinogen-anti-cancer paradox and the role of antioxidants.

Comments

Published version. Anti-Cancer Drug Design, Vol. 1, No. 3 (November 1986): 197-214. Publisher link. © Cognizant Communication Corporation 1986.

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