Cognizant Communication Corporation
Anti-Cancer Drug Design
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm. Electrochemical studies were performed with some of the main types of agents: iminium ions (adenine iminium from alkylating species, iminium metabolite of 6-mercaptopurine, nitidine, other polynuclear iminiums) and metal complexes (Pt(II)diaquodiammine-guanosine, copper salicylaldoximes). Reduction potentials ranged from -0.4 to -1.2 V. Literature data for quinones are presented and radiation is discussed. Based on the theoretical framework, a rationale is offered for the carcinogen-anti-cancer paradox and the role of antioxidants.
Kovacic, Peter; Ames, James R.; Lumme, Paavo; Elo, Hannu; Cox, O.; and Ryan, Michael D., "Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents" (1986). Chemistry Faculty Research and Publications. 600.