Anti-cancer Action of Metal Complexes: Electron Transfer and Oxidative Stress?

Authors

Peter Kovacic, University of Wisconsin - Milwaukee
William J. Popp, University of Wisconsin - Milwaukee
James R. Ames, University of Wisconsin - Milwaukee
Michael D. Ryan, Marquette UniversityFollow

Document Type

Article

Language

eng

Publication Date

12-1988

Publisher

Cognizant Communication Corporation

Source Publication

Anti-Cancer Drug Design

Source ISSN

0266-9536

Abstract

Evidence is presented in support of an electron transfer mechanism for various metal complexes possessing anti-neoplastic properties. Cyclic voltammetry was performed on several metallocenes, bis(acetato)bis(imidazole)Cu(II), and coordination compounds (Cu or Fe) of the anti-tumor agents, bipyridine, phenanthroline, hydroxyurea, diethyldithiocarbamate, and α, α¹-bis(8-hydroxyquinolin-7-yl)-4-methoxytoluene. The favorable reduction potentials ranged from +0.5 to -0.5 V. Electrochemical behavior is correlated in some cases with structure and physiological activity. Relevant literature data are discussed.

Comments

Published version. Anti-Cancer Drug Design, Vol. 3, No. 3 (December 1988): 205-216. Publisher link. © 1986 Cognizant Communication Corporation. Used with permission.

Recommended Citation

Kovacic, Peter; Popp, William J.; Ames, James R.; and Ryan, Michael D., "Anti-cancer Action of Metal Complexes: Electron Transfer and Oxidative Stress?" (1988). Chemistry Faculty Research and Publications. 602.
https://epublications.marquette.edu/chem_fac/602