Cognizant Communication Corporation
Anti-Cancer Drug Design
Evidence is presented in support of an electron transfer mechanism for various metal complexes possessing anti-neoplastic properties. Cyclic voltammetry was performed on several metallocenes, bis(acetato)bis(imidazole)Cu(II), and coordination compounds (Cu or Fe) of the anti-tumor agents, bipyridine, phenanthroline, hydroxyurea, diethyldithiocarbamate, and α, α1-bis(8-hydroxyquinolin-7-yl)-4-methoxytoluene. The favorable reduction potentials ranged from +0.5 to -0.5 V. Electrochemical behavior is correlated in some cases with structure and physiological activity. Relevant literature data are discussed.
Kovacic, Peter; Popp, William J.; Ames, James R.; and Ryan, Michael D., "Anti-cancer Action of Metal Complexes: Electron Transfer and Oxidative Stress?" (1988). Chemistry Faculty Research and Publications. 602.