Regio- and Stereoselective Ruthenium Catalyzed Hydrovinylation of 1,3-Dienes: Application to the Generation of a 20S-Steroidal Sidechain
American Chemical Society
The addition of ethylene to 1,3-dienes and 1-vinylcycloalkenes, catalyzed by two ruthenium complexes, proceeds in a regioselective fashion to afford 3-methyl-1,4-dienes as products. For a steroidal-based 1-vinylcycloalkene, the addition is stereospecific, giving a product with a 20(S) configuration.
He, Zhengjie; Yi, Chae S.; and Donaldson, William A., "Regio- and Stereoselective Ruthenium Catalyzed Hydrovinylation of 1,3-Dienes: Application to the Generation of a 20S-Steroidal Sidechain" (2003). Chemistry Faculty Research and Publications. 80.
Accepted version. Organic Letters, Volume 5, No. 9 (2003): 1567-1569. DOI. © 2003 American Chemical Society. Used with permission.