The C3–C9 segment, (−)-16, of the polyene macrolide antibiotic protomycinolide IV (1a) was prepared in optically pure form from commercially available methyl (S)-2-methyl-3-hydroxypropionate in 12 steps giving 17% yield.
Wasicak, James Thomas and Donaldson, William, "Studies on the Preparation of Protomycinolide IV: Enantioselective Synthesis of the C3–C9 Segment" (1998). Chemistry Faculty Research and Publications. 839.
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