Studies on the Preparation of Protomycinolide IV: Enantioselective Synthesis of the C3–C9 Segment
The C3–C9 segment, (−)-16, of the polyene macrolide antibiotic protomycinolide IV (1a) was prepared in optically pure form from commercially available methyl (S)-2-methyl-3-hydroxypropionate in 12 steps giving 17% yield.
Wasicak, James Thomas and Donaldson, William, "Studies on the Preparation of Protomycinolide IV: Enantioselective Synthesis of the C3–C9 Segment" (1998). Chemistry Faculty Research and Publications. 839.
ADA Accessible Version
Accepted version. Tetrahedron: Asymmetry, Vol. 9, No. 1 (January 16. 1998): 133-140. DOI. © 1998 Elsevier Science Ltd. Used with permission.