Amelioration of Oral Mucositis Pain by NASA Near Infra Red Light Emitting Diodes in Bone Marrow Transplant Patients
Format of Original
Supportive Care in Cancer
PURPOSE: To investigate the use of extra-orally applied near infra-red (NIR) phototherapy for the reduction of oral pain secondary to chemo- and radiation-therapy induced mucositis in adult and pediatric hematopoietic stem cell transplant (HSCT) patients.
METHODS: 80 HSCT were divided into regular (R) and low (L) risk groups, then to experimental (E) and placebo (P) groups, resulting in 4 groups (ER, EL, PR, PL). Experimental subjects received (670 (+/- 10) nm gallium-aluminum-arsinide light emitting diode (LED) device for 80 sec at an ~50mW/cm2 energy density and power exposure of 4J/cm2. Placebo patients received the same procedures, but with a placebo phototherapy (identical device but < 5mW/cm2 energy density). Patients received their respective light therapy once per day starting on the day of the HSCT (Day 0) and continued through Day +14. Blinded evaluators examined the patients 3 times per week and scored their oral tissues and patient-reported pain assessments at each evaluation utilizing the WHO, NCI-CTCAE, and OMAS scales.
RESULTS: Analysis of the mean scores at each observation demonstrate that the extra-oral application of phototherapy resulted in a significant reduction in patient-reported pain between the ER and PR patients (P
CONCLUSION: Phototherapy demonstrated a significant reduction in patient-reported pain as measured by the WHO criteria in this patient population. Improvement trends were noted in most other assessment measurements.
Hodgson, Brian; Margolis, David; Salzman, Donna E.; Eastwood, Dan C.; Tarima, Sergey; Williams, Lisa D.; Sande, Jane E.; Vaughan, William P.; and Whelan, Harry T., "Amelioration of Oral Mucositis Pain by NASA Near Infra Red Light Emitting Diodes in Bone Marrow Transplant Patients" (2012). School of Dentistry Faculty Research and Publications. 1.
Accepted version. Supportive Care in Cancer, Vol. 20, No. 7 (July 2012): 1405-1415. DOI. © 2012 Springer. Used with permission.
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