Format of Original
Journal of Prosthodontics
Original Item ID
DOI: 10.1111/jopr.12465; PubMed Central PMID: 27003096
Clinical advances in the treatment of dentoalveolar defects continue to evolve with the introduction of new innovations in regenerative medicine and tissue bioengineering. Recent developments in tissue engineering are aimed at safely and effectively regenerating a damaged or necrotic area by replenishing its cells and increasing surrounding gene expression. Various techniques have successfully given rise to porous scaffolds being used by clinicians to treat the defect and initiate the repair process. Tissue reconstruction using bioengineered scaffolds is advantageous over traditional autografting, since it prevents the instigation of pain and donor site morbidity while ultimately creating both the environment and machinery needed to induce cell proliferation, migration, and reattachment within the affected area. This review article aims to describe and review the available literature regarding the regenerative capacity of natural polymers used for the treatment of dentoalveolar defects. The repair mechanisms, advantages of protein and polysaccharide derivatives, and the potential of stem cell therapy are discussed.
Jazayeri, Hossein E.; Fahmy, Mina D.; Razavi, Mehdi; Stein, Brett E.; Nowman, Aatif; Masri, Radi; and Tayebi, Lobat, "Dental Applications of Natural-Origin Polymers in Hard and Soft Tissue Engineering" (2016). School of Dentistry Faculty Research and Publications. 189.
Accepted version. Journal of Prosthdontics, Vol. 25, No. 6 (August 2016): 510-517. DOI. © 2016 John Wiley & Sons, Inc. Used with permission.