Oral hairy leukoplakia (OHL) is a disease of the mucosa first described in 1984. This pathology is associated with Epstein-Barr virus (EBV) and occurs mostly in people with HIV infection, both immunocompromised and immunocompetent, and can affect patients who are HIV negative. [1, 2] The first case in an HIV-negative patient was reported in 1999 in a 56-year-old patient with acute lymphocytic leukemia. Later, many cases were reported in heart, kidney, and bone marrow transplant recipients and patients with hematological malignancies. [3, 4]
Cade, James E.; Vinson, Richard P.; Burgess, Jeff; Agarwala, Sanjiv S.; Lynch, Denis P.; and Stafford, Gary L., "Hairy Leukoplakia" (2017). School of Dentistry Faculty Research and Publications. 252.