Date of Award

Fall 2008

Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)



First Advisor

Kincaid, James R.

Second Advisor

Haworth, Daniel T.

Third Advisor

Sem, Daniel S.


Heme proteins, which are ubiquitous in physiological systems, are key components involved in many biological processes, having several different biological functions. For example, myoglobin (Mb) and hemoglobin (Hb) are heme proteins whose biological functions are to reversibly bind an oxygen molecule in order to store and transport molecular oxygen within blood and muscle tissues; cytochromes P-450 (CYPs) play a critical role in activation and cleavage of molecular oxygen to generate redox intermediates which catalyze hydroxylation or epoxidation of their substrates 4; peroxidases mainly participate in an oxidation reaction of organic and inorganic compounds by utilizing hydrogen peroxide as a primary substrate; catalases (CATs) serve a key biological role to eliminate toxic hydrogen peroxide by catalyzing the conversion of hydrogen peroxide to water and oxygen molecules...



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