Date of Award

Fall 1969

Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)


Biological Sciences

First Advisor

Smith, Oliver H.

Second Advisor

Irr, Joseph

Third Advisor

Marzluf, George


Since Mendel's early observations on the genetic determination of qualitative and quantitative characteristics of an individual, man has sought to understand the nature of the gene and its control of biological processes. This understanding has progressed from gross morphological aspects of an inheritable characteristic to the biochemical and molecular nature of the factors which underlie these characteristics. One of the first clear recognitions of biochemical expression of inherited variability was made in 1908 by A, E, Garrod (quoted by Sutton, 1961), He clearly set forth the concept that some inherited diseases in man were the result of a metabolic block which resulted in abnormal metabolism, The work of Beadle and Tatum (1941) and their concept of "one gene-one enzyme" demonstrated that gene action could be described in biochemical terms...



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