Date of Award
Spring 1995
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Kincaid, James R.
Second Advisor
Haworth, Daniel T.
Third Advisor
Nevitz, Mark G.
Abstract
In the past two decades a number spectroscopic techniques and physicochemical measurements have been utilized to identify the conformation of the active sites of biologically important molecules: e.g., hemoglobin, myoglobin, cytochromes a, b, b5, c, cytochrome P-450, cytochrome c oxidase, peroxidases and catalases. These biological macromolecules perform several important functions in living organisms including oxygen transport and storage (hemoglobin and myoglobin)1-4 , hydrogen peroxide utilization and decomposition (peroxidase and catalases)2,5,6, catalytic oxidation hydrocarbons (cytochrome P-450)5,7, electron transfer (cytochromes b, c)1,2,8 and oxygen reduction (cytochrome oxidase)5,9...