Date of Award

Spring 1995

Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)



First Advisor

Kincaid, James R.

Second Advisor

Haworth, Daniel T.

Third Advisor

Nevitz, Mark G.


In the past two decades a number spectroscopic techniques and physicochemical measurements have been utilized to identify the conformation of the active sites of biologically important molecules: e.g., hemoglobin, myoglobin, cytochromes a, b, b5, c, cytochrome P-450, cytochrome c oxidase, peroxidases and catalases. These biological macromolecules perform several important functions in living organisms including oxygen transport and storage (hemoglobin and myoglobin)1-4 , hydrogen peroxide utilization and decomposition (peroxidase and catalases)2,5,6, catalytic oxidation hydrocarbons (cytochrome P-450)5,7, electron transfer (cytochromes b, c)1,2,8 and oxygen reduction (cytochrome oxidase)5,9...



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