Date of Award

Summer 2009

Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)


Biological Sciences

First Advisor

Waring, Gail

Second Advisor

Karrer, Kathleen

Third Advisor

Munroe, Stephen


Cells in most multicellular organisms are surrounded by a complex network of mixed molecules, the extracellular matrix (ECM). Assembled in complicated environments, extracellular matrix networks provide numerous functions, the most obvious being mechanical support and a substrate for anchoring cells and organs. More importantly, extracellular matrice host secreted molecules regulating cell differentiation, tissue remodeling, and morphology. To perform these structural and regulatory functions, the ECM has to be properly assembled...



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