Date of Award


Document Type

Dissertation - Restricted

Degree Name

Doctor of Philosophy (PhD)



First Advisor

Ronald K. Kalkhoff

Second Advisor

Harold F. Hardman

Third Advisor

Deane N. Calvert

Fourth Advisor

Bert K.B. Lum


The importance of the liver in metabolism makes it a desirable organ for many investigations. Part I of the dissertation involved the study of the metabolic alteration of 1,1'-trimethylene-bis-(4-aldoximinopyridinium) dibromide (TMB-4) in the isolated perfused rat liver system. This compound is an important therapeutic agent in poisoning by the alkylphosphate anticholinesterase compounds, however, there have been few reports dealing with its metabolism in the body. Part II was devoted to the study of hepatic lipid synthesis in alloxan diabetic rats and the relationship to hepatic and serum substrate levels. Since diabetes mellitus is a major disorder in medicine associated with disturbances in carbohydrate, protein, nucleic acid and lipid metabolism, it is important to understand the contribution of various tissues to the disturbances.



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