Date of Award
4-1968
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Medical
First Advisor
Ronald K. Kalkhoff
Second Advisor
Harold F. Hardman
Third Advisor
Deane N. Calvert
Fourth Advisor
Bert K.B. Lum
Abstract
The importance of the liver in metabolism makes it a desirable organ for many investigations. Part I of the dissertation involved the study of the metabolic alteration of 1,1'-trimethylene-bis-(4-aldoximinopyridinium) dibromide (TMB-4) in the isolated perfused rat liver system. This compound is an important therapeutic agent in poisoning by the alkylphosphate anticholinesterase compounds, however, there have been few reports dealing with its metabolism in the body. Part II was devoted to the study of hepatic lipid synthesis in alloxan diabetic rats and the relationship to hepatic and serum substrate levels. Since diabetes mellitus is a major disorder in medicine associated with disturbances in carbohydrate, protein, nucleic acid and lipid metabolism, it is important to understand the contribution of various tissues to the disturbances.