Date of Award
4-1970
Document Type
Dissertation - Restricted
Degree Name
Doctor of Philosophy (PhD)
Department
Medical
First Advisor
James M. Fujimoto
Second Advisor
Deane N. Calvert
Third Advisor
Howard M. Klitgaard
Fourth Advisor
Richard I.H. Wang
Fifth Advisor
John P. Kampine
Abstract
The Sperber technique of unilateral renal portal infusion in hens was used to study the renal tubular transport and metabolism of morphine and other agents. Morphine was actively transported across the renal tubules and was metabolized within the chicken kidney to morphine-3-ethereal sulfate (MES). The transport of morphine was inhibited by the organic base transport system blocking agents, cyanine 863 and mepiperphenidol. Morphine was also shown to block the transport of the base, tetraethyl ammonium. The organic acid transport inhibitor, probenecid, did not inhibit the transport of morphine and had no effect on the excretion of MES that was formed from morphine inside the renal tubular cell.